Authors
Nikita Chapurin, Rodney J Schlosser, Jorge Gutierrez, Jess C Mace, Timothy L Smith, Todd E Bodner, Sofia Khan, Jennifer K Mulligan, Jose L Mattos, Jeremiah A Alt, Vijay R Ramakrishnan, Zachary M Soler
Publication date
2024/4
Journal
International Forum of Allergy & Rhinology
Volume
14
Issue
4
Pages
765-774
Description
Background
It is unclear whether chronic rhinosinusitis (CRS) endotypes show a differential response to endoscopic sinus surgery (ESS). We explored patient mucous inflammatory cytokine expression and associations with patient‐reported and clinically measured post‐operative outcome measures.
Methods
Patients with CRS were prospectively recruited between 2016 and 2021 into a national multicenter, observational study. Mucus was collected from the olfactory cleft preoperatively and evaluated for 26 biomarkers using cluster analysis. Patient‐reported outcome measures included the 22‐item Sino‐Nasal Outcome Test (SNOT‐22) and Questionnaire of Olfactory Dysfunction (QOD). Additional clinical measures of disease severity included threshold, discrimination, and identification (TDI) scores using “Sniffin’ Sticks” testing and Lund–Kennedy endoscopic score (LKES).
Results
A total of 115 patients were …
Total citations
20241
Scholar articles
N Chapurin, RJ Schlosser, J Gutierrez, JC Mace… - International Forum of Allergy & Rhinology, 2024