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Prior work has described 5 domains within the 22‐item Sino‐Nasal Outcomes Test (SNOT‐22) that allow for stratification of symptoms into similar clusters and that can be used to direct therapy. Although the outcomes of various interventions on these symptom domains have been reported, minimal clinically important difference (MCID) values have not been investigated, which has limited clinical interpretation of these results.

This study was designed as a secondary analysis of a prospective, multi‐institutional, observational cohort. A total of 276 patients with medically refractory CRS who underwent surgical management were enrolled. Distribution‐based methods (half‐standard deviation, standard error of measurement, Cohen's d, and the minimum detectable change) were used to compute MCID values for both SNOT‐22 total and domain scores. The Medical Outcomes Study Short Form …