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(MIR125A, MIR125B1, and MIR125B2) that are located on different chromosomes but share identical seed sequences. These genes are among the most highly expressed microRNAs in hematopoietic stem cells (HSCs), with expression levels declining during hematopoietic maturation. There is substantial evidence implicating miR-125 in the regulation of HSC function. Enforced expression of miR-125 family members enhances HSC engraftment and self-renewal activity and promotes skewing toward the myeloid lineage. 2 Indeed, expression of miR-125a confers long-term repopulating activity on human and mouse multipotent progenitors. 3 There is evidence implicating miR-125b in the pathogenesis of hematologic malignancies. miR-125b is highly expressed in a subset of acute myeloid leukemia (AML), including those with t (2: 11)(p21; q23), AML1/ETO, and PML/RARa translocations. High miR-125b …