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We calculated the reliable change index (RCI) and clinically significant change (CSC) values for two widely used measures of posttraumatic stress disorder (PTSD): The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) and the PTSD Checklist for DSM-5 (PCL-5) and examined how symptom changes at these thresholds related to improvements in psychosocial functioning. We used data from three independent samples of male military veterans, including two randomized controlled trials for PTSD (N= 198 for Sample 1 and N= 102 for Sample 2) and a cross-sectional study of primary care patients (N= 228). For Sample 1, within-person change in CAPS-5 and PCL-5 scores of≥ 13 and 15, respectively, was indicative of reliable change. For Sample 2, within-person change in CAPS-5 and PCL-5 scores of≥ 12 and 18, respectively, was indicative of reliable change. Scores of≤ 8 and 28 on the CAPS-5 and PCL …