Authors
Ferdinand Marlétaz, Panos N Firbas, Ignacio Maeso, Juan J Tena, Ozren Bogdanovic, Malcolm Perry, Christopher DR Wyatt, Elisa de La Calle-Mustienes, Stephanie Bertrand, Demian Burguera, Rafael D Acemel, Simon J Van Heeringen, Silvia Naranjo, Carlos Herrera-Ubeda, Ksenia Skvortsova, Sandra Jimenez-Gancedo, Daniel Aldea, Yamile Marquez, Lorena Buono, Iryna Kozmikova, Jon Permanyer, Alexandra Louis, Beatriz Albuixech-Crespo, Yann Le Petillon, Anthony Leon, Lucie Subirana, Piotr J Balwierz, Paul Edward Duckett, Ensieh Farahani, Jean-Marc Aury, Sophie Mangenot, Patrick Wincker, Ricard Albalat, Èlia Benito-Gutiérrez, Cristian Cañestro, Filipe Castro, Salvatore D’Aniello, David EK Ferrier, Shengfeng Huang, Vincent Laudet, Gabriel AB Marais, Pierre Pontarotti, Michael Schubert, Hervé Seitz, Ildiko Somorjai, Tokiharu Takahashi, Olivier Mirabeau, Anlong Xu, Jr-Kai Yu, Piero Carninci, Juan Ramon Martinez-Morales, Hugues Roest Crollius, Zbynek Kozmik, Matthew T Weirauch, Jordi Garcia-Fernàndez, Ryan Lister, Boris Lenhard, Peter WH Holland, Hector Escriva, Jose Luis Gómez-Skarmeta, Manuel Irimia
Publication date
2018/12/6
Journal
Nature
Volume
564
Issue
7734
Pages
64-70
Publisher
Nature Publishing Group UK
Description
Vertebrates have greatly elaborated the basic chordate body plan and evolved highly distinctive genomes that have been sculpted by two whole-genome duplications. Here we sequence the genome of the Mediterranean amphioxus (Branchiostoma lanceolatum) and characterize DNA methylation, chromatin accessibility, histone modifications and transcriptomes across multiple developmental stages and adult tissues to investigate the evolution of the regulation of the chordate genome. Comparisons with vertebrates identify an intermediate stage in the evolution of differentially methylated enhancers, and a high conservation of gene expression and its cis-regulatory logic between amphioxus and vertebrates that occurs maximally at an earlier mid-embryonic phylotypic period. We analyse regulatory evolution after whole-genome duplications, and find that—in vertebrates—over 80% of broadly expressed gene …
Scholar articles
F Marlétaz, PN Firbas, I Maeso, JJ Tena, O Bogdanovic… - Nature, 2018