Authors
David O Oluwole, Fatma Aslıhan Sarı, Earl Prinsloo, Edith Dube, Abdulcelil Yuzer, Tebello Nyokong, Mine Ince
Publication date
2018/10/5
Journal
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Volume
203
Pages
236-243
Publisher
Elsevier
Description
The syntheses of two zinc(II) phthalocyanines (ZnPcs) having either imidazole (ZnPc 1) or pyridiloxy (ZnPc 2) moieties as their macrocycle substituents are reported. Quaternization of the ZnPcs with methyl iodide afforded water soluble cationic phthalocyanines. The photophysical, photochemical properties and photodynamic therapy (PDT) activity of the ZnPcs were studied in solution. The fluorescence quantum yield and lifetime of ZnPc 1 were higher as compared to ZnPc 2. ZnPc 2 afforded higher triplet state (ΦT) and singlet oxygen quantum yields (ΦΔ) in comparison to ZnPc 1. The PDT activity of ZnPcs was investigated against human breast adenocarcinoma cells (MCF–7). The two compounds afforded a very minimal in vitro dark cytotoxicity with 85% viable cells at concentration ≤80 μM. On irradiation of the cells having the ZnPcs, ≥50% cell death was recorded for ZnPc 1 which was also evidenced by the …
Scholar articles
DO Oluwole, FA Sarı, E Prinsloo, E Dube, A Yuzer… - Spectrochimica Acta Part A: Molecular and …, 2018