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This paper presents the meshless generalized finite difference method (GFDM) in conjunction with the truncated treatments of infinite domain for simulating water wave interactions with multiple-bottom-seated-cylinder-array structures. In the proposed scheme, the truncated treatments are introduced to deal with the infinite domain. Based on the moving least squares theory and second-order Taylor series expansion, the GFDM approximation formulation is constructed for water wave-structure interactions. It introduces the stencil selection algorithms to choose the stencil support of a certain node from the whole discretization nodes. In comparison with traditional finite difference methods, the proposed GFDM is free of mesh and available for irregular discretization nodes. Numerical investigations are presented to demonstrate the effectiveness of the proposed GFDM with two truncated treatments, absorbing boundary …