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Pressure ulcers are among the most common secondary injuries following spinal cord injury (SCI). A general consensus is that an effective prevention program would greatly reduce the incidence and prevalence of pressure ulcers. Increased risks for pressure ulcers following SCI are related to immobility, neurological impairments, and changes to biomechanical and microvascular properties of the soft tissue. Programs to minimize these risk factors might include technology to quantitatively assess tissue viability and management of tissue loading.