Authors
Nils Opel, Ronny Redlich, Katharina Dohm, Dario Zaremba, Janik Goltermann, Jonathan Repple, Claas Kaehler, Dominik Grotegerd, Elisabeth J Leehr, Joscha Böhnlein, Katharina Förster, Susanne Meinert, Verena Enneking, Lisa Sindermann, Fanni Dzvonyar, Daniel Emden, Ramona Leenings, Nils Winter, Tim Hahn, Harald Kugel, Walter Heindel, Ulrike Buhlmann, Bernhard T Baune, Volker Arolt, Udo Dannlowski
Publication date
2019/4/1
Journal
The Lancet Psychiatry
Volume
6
Issue
4
Pages
318-326
Publisher
Elsevier
Description
Background
Childhood maltreatment is a leading environmental risk factor for an unfavourable course of disease in major depressive disorder. Both maltreatment and major depressive disorder are associated with similar brain structural alterations suggesting that brain structural changes could mediate the adverse influence of maltreatment on clinical outcome in major depressive disorder. However, longitudinal studies have not been able to confirm this hypothesis. We therefore aimed to clarify the relationship between childhood trauma, brain structural alterations, and depression relapse in a longitudinal design.
Methods
We recruited participants at the Department of Psychiatry, University of Münster, Germany, from the Münster Neuroimage Cohort for whom 2-year longitudinal clinical data were available. Baseline data acquisition comprised clinical assessments, structural MRI, and retrospective assessment of the …
Scholar articles
N Opel, R Redlich, K Dohm, D Zaremba, J Goltermann… - The Lancet Psychiatry, 2019