Authors
Robert K Shepherd, Lloyd A Roberts, Antonio G Paolini
Publication date
2004/12
Journal
European Journal of Neuroscience
Volume
20
Issue
11
Pages
3131-3140
Publisher
Blackwell Science Ltd
Description
Loss of cochlear hair cells in the rat initiates degenerative change within the primary auditory neurons (ANs) of the cochlea. These degenerative changes include loss of peripheral processes, demyelination and ultimately cell death. This pathology will affect the biophysical processes involved in action potential generation and propagation to an electrical stimulus via a cochlear implant. We measured the response properties of ANs, with particular reference to their refractory behaviour, in normal, short‐ (9 weeks) and long‐term (> 52 weeks) deafened rats. AN loss was moderate in the short‐term and severe in the long‐term deafened animals. AN activity was elicited using a brief electrical stimulus delivered via a bipolar electrode array implanted into the cochlea. The general response properties of ANs recorded from deafened cochleae were similar to those observed in normal cochleae, i.e. a monotonic increase in …
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RK Shepherd, LA Roberts, AG Paolini - European Journal of Neuroscience, 2004