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A significant growth in Unmanned Aircraft System (UAS) operations has been observed over the past decade, largely driven by the emergence of new commercial opportunities and use-cases. This has posed new technological and regulatory challenges in order to address the complex safety, efficiency and sustainability requirements associated with UAS operations in an increasingly congested airspace. The growing need for trusted autonomy in UAS operations imposes demanding performance requirements on Navigation and Guidance Systems (NGS), both in terms of accuracy, integrity, continuity and availability. In most current NGS implementations, system autonomy is tightly constrained within a specified set of operational and environmental conditions through a large number of explicit rules. Recent breakthroughs in Artificial Intelligence (AI)-based methods and the emergence of highly-parallelized …