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Integrated System Health Management (ISHM) is a promising technology that fuses sensor data and historical state-of-health information of components and subsystems to provide actionable information and enable intelligent decision-making regarding the operation and maintenance of aerospace systems. ISHM fundamentally relies on assessments and predictions of system health, including the early detection of failures and estimation of Remaining Useful Life (RUL). Model-based, data-driven or hybrid reasoning techniques can be utilized to maximise the timeliness and reliability of diagnosis and prognosis information. The benefits of ISHM include enhancing the maintainability, reliability, safety and performance of systems. The next evolution of the ISHM concept, Intelligent Health and Mission Management (IHMM), delves deeper into the utilization of on-line system health predictions to modify mission profiles …