Authors
Justin S Smith, Edward F Chang, Kathleen R Lamborn, Susan M Chang, Michael D Prados, Soonmee Cha, Tarik Tihan, Scott VandenBerg, Michael W McDermott, Mitchel S Berger
Publication date
2008/3/10
Journal
Journal of Clinical Oncology
Volume
26
Issue
8
Pages
1338-1345
Publisher
American Society of Clinical Oncology
Description
Purpose
The prognostic role of extent of resection (EOR) of low-grade gliomas (LGGs) is a major controversy. We designed a retrospective study to assess the influence of EOR on long-term outcomes of LGGs.
Patients and Methods
The study population (N = 216) included adults undergoing initial resection of hemispheric LGG. Region-of-interest analysis was performed to measure tumor volumes based on fluid-attenuated inversion-recovery (FLAIR) imaging.
Results
Median preoperative and postoperative tumor volumes and EOR were 36.6 cm3 (range, 0.7 to 246.1 cm3), 3.7 cm3 (range, 0 to 197.8 cm3) and 88.0% (range, 5% to 100%), respectively. There was no operative mortality. New postoperative deficits were noted in 36 patients (17%); however, all but four had complete recovery. There were 34 deaths (16%; median follow-up, 4.4 years). Progression and …
Total citations
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Scholar articles
JS Smith, EF Chang, KR Lamborn, SM Chang… - Journal of Clinical Oncology, 2008