Authors
Mark E Linskey, David W Andrews, Anthony L Asher, Stuart H Burri, Douglas Kondziolka, Paula D Robinson, Mario Ammirati, Charles S Cobbs, Laurie E Gaspar, Jay S Loeffler, Michael McDermott, Minesh P Mehta, Tom Mikkelsen, Jeffrey J Olson, Nina A Paleologos, Roy A Patchell, Timothy C Ryken, Steven N Kalkanis
Publication date
2010/1
Source
Journal of neuro-oncology
Volume
96
Pages
45-68
Publisher
Springer US
Description
Question
Should patients with newly-diagnosed metastatic brain tumors undergo stereotactic radiosurgery (SRS) compared with other treatment modalities?
Target population
These recommendations apply to adults with newly diagnosed solid brain metastases amenable to SRS; lesions amenable to SRS are typically defined as measuring less than 3 cm in maximum diameter and producing minimal (less than 1 cm of midline shift) mass effect.
Recommendations
SRS plus WBRT vs. WBRT alone
Level 1 Single-dose SRS along with WBRT leads to significantly longer patient survival compared with WBRT alone for patients with single metastatic brain tumors who have a KPS ≥ 70.
Level 2 Single-dose SRS along with WBRT is superior in terms of local tumor control and …
Total citations
Scholar articles
ME Linskey, DW Andrews, AL Asher, SH Burri… - Journal of neuro-oncology, 2010