Authors
Peter P Roy-Byrne, Kenneth P Pages, Joan E Russo, Craig Jaffe, Arthur W Blume, Elizabeth Kingsley, Deborah S Cowley, Richard K Ries
Publication date
2000/4/1
Journal
Journal of Clinical Psychopharmacology
Volume
20
Issue
2
Pages
129-136
Publisher
LWW
Description
Depression is the most common comorbid psychiatric illness in patients with alcohol dependence. This double-blind study tested the efficacy of nefazodone versus placebo for the treatment of depression in actively drinking alcohol-dependent patients who were also participating in weekly group treatment for alcoholism. Sixty-four subjects with major depression disorder and alcohol dependence with a history of at least one prior episode of depression when not drinking were randomly assigned to receive 12 weeks of either nefazodone or placebo and participated in a weekly psychoeducational group on alcoholism. Subjects were assessed every 2 weeks for depression, anxiety, side effects, and drinking frequency. Subjects taking nefazodone were significantly more likely to complete the study (62%) than those taking placebo (34%). Analyses of covariance using drinks per week as a time-dependent covariate …
Total citations
Scholar articles
PP Roy-Byrne, KP Pages, JE Russo, C Jaffe… - Journal of Clinical Psychopharmacology, 2000
P Roy-Byrne, KP Pages, JE Russo, AW Blume, C Jaffe… - J Clin Psychopharmacol, 2000