Authors
Ellen Sidransky, Michael A Nalls, Jan O Aasly, Judith Aharon-Peretz, Grazia Annesi, Egberto R Barbosa, Anat Bar-Shira, Daniela Berg, Jose Bras, Alexis Brice, C-M Chen, Lorraine N Clark, Christel Condroyer, Elvira V De Marco, Alexandra Dürr, Michael J Eblan, Stanley Fahn, Matthew J Farrer, H-C Fung, Ziv Gan-Or, Thomas Gasser, Ruth Gershoni-Baruch, Nir Giladi, Alida Griffith, Tanya Gurevich, Cristina Januario, Peter Kropp, Anthony E Lang, G-J Lee-Chen, Suzanne Lesage, Karen Marder, Ignacio F Mata, Anat Mirelman, Jun Mitsui, Ikuko Mizuta, Giuseppe Nicoletti, Catarina Oliveira, Ruth Ottman, Avi Orr-Urtreger, Lygia V Pereira, Aldo Quattrone, Ekaterina Rogaeva, Arndt Rolfs, Hanna Rosenbaum, Roberto Rozenberg, Ali Samii, Ted Samaddar, Claudia Schulte, Manu Sharma, Andrew Singleton, Mariana Spitz, E-K Tan, Nahid Tayebi, Tatsushi Toda, André R Troiano, Shoji Tsuji, Matthias Wittstock, Tyra G Wolfsberg, Y-R Wu, Cyrus P Zabetian, Yi Zhao, Shira G Ziegler
Publication date
2009/10/22
Journal
New England Journal of Medicine
Volume
361
Issue
17
Pages
1651-1661
Publisher
Massachusetts Medical Society
Description
Background
Recent studies indicate an increased frequency of mutations in the gene encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among patients with Parkinson's disease. We aimed to ascertain the frequency of GBA mutations in an ethnically diverse group of patients with Parkinson's disease.
Methods
Sixteen centers participated in our international, collaborative study: five from the Americas, six from Europe, two from Israel, and three from Asia. Each center genotyped a standard DNA panel to permit comparison of the genotyping results across centers. Genotypes and phenotypic data from a total of 5691 patients with Parkinson's disease (780 Ashkenazi Jews) and 4898 controls (387 Ashkenazi Jews) were analyzed, with multivariate logistic-regression models and the Mantel–Haenszel procedure used to estimate odds ratios across centers.
Results
All 16 centers …
Total citations
Scholar articles
E Sidransky, MA Nalls, JO Aasly, J Aharon-Peretz… - New England Journal of Medicine, 2009