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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by progressive cognitive impairment. Growing evidence suggests the endosomal pathway is altered in AD. For instance, enlargement of endosomes and abnormal tau and amyloid precursor protein endocytosis have been described in early AD. Multivesicular bodies (MVBs) are membrane-bound organelles that are representative of endosomal activity. In addition, MVBs have been associated with mitochondrial and synaptic function, which are known to correlate with cognitive performance in AD. Nevertheless, the characterization of MVBs in the pathogenesis of AD has never been addressed. In the present study, human brain samples from autopsies of three subjects with no neurological alterations and three subjects with different degrees of AD pathology were examined. Sections containing the CA1 field and the Enthorinal …