Authors
Gerdien Belle-van Meerkerk, Maarten J Cramer, Johanna M Kwakkel-van Erp, Mochamed A Nugroho, Sabrin Tahri, Harold W de Valk, Ed A van de Graaf
Publication date
2013/6/1
Journal
The Journal of Heart and Lung Transplantation
Volume
32
Issue
6
Pages
609-614
Publisher
Elsevier
Description
BACKGROUND
This study investigated the prevalence of pulmonary hypertension (PH) in cystic fibrosis (CF) patients awaiting lung transplantation (LTx) and its influence on survival. We also explored the feasibility of using echocardiography as a first assessment for diagnosing PH.
METHODS
The study included 93 CF patients (46 women [50%]) evaluated for LTx between 2001 and 2010. Median age was 29 years. PH was defined as a mean pulmonary artery pressure (mPAP) measured by right heart catheterization (mPAPcath) of ≥ 25mm Hg with a wedge pressure of ≤ 15mm Hg. Echocardiographic results were divided into 3 categories based on current guidelines as “unlikely,” “possible,” or “likely” to have PH.
RESULTS
In 23 patients (25%) the mPAPcath was between 25 and 35mm Hg, and 1 (1%) had severe PH (mPAPcath of ≥ 35mm Hg). PH did not influence survival after enlistment (p = 0.7) and after …
Scholar articles
G Belle-van Meerkerk, MJ Cramer… - The Journal of Heart and Lung Transplantation, 2013