Authors
Tobias Heigl, Berta Saez-Gimenez, Anke Van Herck, Janne Kaes, Annelore Sacreas, Hanne Beeckmans, Gene PL Ambrocio, Hanneke Kwakkel-Van Erp, Sofie Ordies, Arno Vanstapel, Stijn E Verleden, Arne P Neyrinck, Laurens J Ceulemans, Dirk E Van Raemdonck, Erik Verbeken, Geert M Verleden, Robin Vos, Bart Vanaudenaerde
Publication date
2021/2/1
Journal
Transplant Immunology
Volume
64
Pages
101352
Publisher
Elsevier
Description
In recent years, the utility of vascular complement factor 4d (C4d) deposition as diagnostic tool for antibody mediated rejection (AMR) after lung transplantation, has become a controversial issue. We aimed to pinpoint the problematic nature of C4d as biomarker with a simple experiment.
We quantified C4d in broncho-alveolar lavage (BAL) of lung transplant patients with diverse post-transplant complications in 3 different settings of clinically clear cases of: 1/ chronic lung allograft dysfunction (CLAD); 2/ acute complications acute rejection (AR), lymphocytic bronchiolitis (LB), antibody-mediated rejection (AMR) and respiratory infection (INF); 3/ patients with parallel C4d immunostaining and Anti-HLA. All groups were compared to BAL of stable patients. C4d was measured via standard ELISA.
C4d was increased in CLAD, predominantly in RAS (p = 0.0026) but not in BOS (p = 0.89). C4d was increased in all acute events …
Total citations
Scholar articles
T Heigl, B Saez-Gimenez, A Van Herck, J Kaes… - Transplant Immunology, 2021