Authors
Elisabeth A Kastelijn, Coline HM van Moorsel, Karin M Kazemier, Suzan M Roothaan, Henk JT Ruven, Johanna M Kwakkel-van Erp, Ed A van de Graaf, Pieter Zanen, Diana A van Kessel, Jan C Grutters
Publication date
2011/12
Journal
Fibrogenesis & tissue repair
Volume
4
Pages
1-11
Publisher
BioMed Central
Description
Background
Caveolin 1 (Cav-1) is the primary structural component of cell membrane invaginations called 'caveolae'. Expression of Cav-1 is implicated in the pathogenesis of pulmonary fibrosis. Genetic polymorphisms in the CAV1 gene influence the function of Cav-1 in malignancies and associate with renal allograft fibrosis. Chronic allograft rejection after lung transplantation, called 'bronchiolitis obliterans syndrome' (BOS), is also characterised by the development of fibrosis.
In this study, we investigated whether CAV1 genotypes associate with BOS and whether Cav-1 serum levels are influenced by the CAV1 genotype and can be used as a biomarker to predict the development of BOS.
Methods
Twenty lung transplant recipients with BOS (BOSpos), ninety without BOS (BOSneg) and four hundred twenty-two healthy individuals donated DNA …
Total citations
2013201420152016201720182019202020212022202312522111
Scholar articles
EA Kastelijn, CHM van Moorsel, KM Kazemier… - Fibrogenesis & tissue repair, 2011