Authors
Jorunn Kirkeleit, Trond Riise, Mathias Wielscher, Simone Accordini, Anne-Elie Carsin, Julie Dratva, Karl A Franklin, Judith Garcia-Aymerich, Deborah Jarvis, Benedicte Leynaert, Caroline J Lodge, Francisco Gomez Real, Vivi Schlünssen, Angelo Guido Corsico, Joachim Heinrich, Matthias Holm, Christer Janson, Bryndis Benediktsdóttir, Rain Jogi, Shyamali C Dharmage, Marjo-Riitta Järvelin, Cecilie Svanes
Publication date
2023/12/1
Journal
EClinicalMedicine
Volume
66
Publisher
Elsevier
Description
Background
We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults followed for more than 20 years and with up to three lung function measurements.
Methods
Participants (20–68 years) in the ECRHS and NFBC1966 cohort studies followed in the periods 1991–2013 and 1997–2013, respectively, were included. Mean annual decline in maximum forced expired volume in 1 s (FEV1) and forced vital capacity (FVC) were main outcomes. Associations between early life risk factors and change in lung function were estimated using mixed effects linear models adjusted for sex, age, FEV1, FVC and height at baseline, accounting for personal smoking.
Findings
Decline in lung function was accelerated in participants with mothers that smoked during pregnancy (FEV1 2.3 …
Total citations
20242
Scholar articles
J Kirkeleit, T Riise, M Wielscher, S Accordini, AE Carsin… - EClinicalMedicine, 2023