Authors
Loreen Thürmann, Mario Bauer, Maike Ferland, Marey Messingschlager, Tamara Schikowski, Andrea von Berg, Joachim Heinrich, Gunda Herberth, Irina Lehmann, Marie Standl, Saskia Trump
Publication date
2023/11
Journal
Hypertension
Volume
80
Issue
11
Pages
2425-2436
Publisher
Lippincott Williams & Wilkins
Description
BACKGROUND
Inflammatory processes have been suggested as a culprit of vascular damage in pediatric hypertension. We aimed to investigate transcriptional changes of immune modulators and determine their association with office blood pressure in adolescents who were not diagnosed with hypertension at the time of the study visit.
METHODS
Office blood pressure measurements and blood samples were taken from adolescents of 2 German birth cohorts, GINIplus (The German Infant Study on the Influence of Nutrition Intervention Plus Air Pollution and Genetics on Allergy Development; discovery cohort, n=1219) and LISA (Influences of Lifestyle-related factors on the Immune System and the Development of Allergies in Childhood; validation cohort, n=809), during the 15-year follow-up visit and categorized based on the European Society of Hypertension Guideline. Hs-CRP (high-sensitivity C-reactive …
Total citations
Scholar articles
L Thürmann, M Bauer, M Ferland, M Messingschlager… - Hypertension, 2023