Authors
Mark Granada, Jemma Wilk, Marina Tuzova, David Strachan, Stephan Weidinger, Eva Albrecht, Christian Gieger, Joachim Heinrich, Blanca E Himes, Matthew Hunninghake, Juan C Celedon, Scott T Weiss, William Cruikshank, Lindsay Farrer, David Center, George T O'Connor
Publication date
2011/5
Book
D101. ASTHMA GENETICS
Pages
A6174-A6174
Publisher
American Thoracic Society
Description
METHODS: A genome wide association study (GWAS) for total IgE concentration was performed in 6,819 participants from the Framingham Heart Study (FHS). Seventy of the top SNPs were selected based on p-values and evaluated in a meta-analysis with five independent populations from the KORA, BBC, and CAMP cohorts. RESULTS: SNPs located in the region of three genes,,, and, were found to have genome-wide significance in FHS. The FCER1A STAT6 IL-13 most significant SNPs from the three regions were rs2251746 (, p-value 2.11 x10), rs1059513 (, p-value 2.87 x10), and FCER1A-12 STAT6-08 rs1295686 (, p-value 3.55 x10). Four additional gene regions reached genome-wide statistical significance in the meta-analysis: IL-13-08
,, and. An SNP recently reported to be associated with IgE by the GABRIEL Consortium had a HLA-A DARC, HLA-DQA2 HLA-G HLA-DRB1 weaker association (p= 0.06) in …
Scholar articles
M Granada, J Wilk, M Tuzova, D Strachan, S Weidinger… - D101. ASTHMA GENETICS, 2011