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Chronic renal injury can be mediated by angiotensin II (ANG II) and prostanoids through hemodynamic and inflammatory mechanisms and attenuated by individual suppression of these mediators. In rats with ⅚ renal ablation (Nx), we investigated 1) the intrarenal distribution of COX-2, ANG II, and the AT₁ receptor (AT₁R); 2) the renoprotective and antiinflammatory effects of an association between the AT₁R blocker, losartan (Los), and the gastric sparing anti-inflammatory nitroflurbiprofen (NOF). Adult male Munich-Wistar rats underwent Nx or sham operation (S), remaining untreated for 30 days, after which renal structure was examined in 12 Nx rats (Nx_pre). The remaining rats were followed during an additional 90 days, distributed among 4 treatment groups: Nx_V (vehicle), Nx_Los (Los), Nx_NOF (NOF), and Nx_Los/NOF (Los/NOF). Nx_pre rats exhibited marked albuminuria, hypertension, glomerulosclerosis, interstitial …