Authors
John M Seymour, Katie Ward, Paul S Sidhu, Zudin Puthucheary, Joerg Steier, Caroline J Jolley, Gerrard Rafferty, Michael I Polkey, John Moxham
Publication date
2009/5/1
Journal
Thorax
Volume
64
Issue
5
Pages
418-423
Publisher
BMJ Publishing Group Ltd
Description
Background
Quadriceps weakness and loss of muscle mass predict mortality in chronic obstructive pulmonary disease (COPD). It was hypothesised that a reduced quadriceps cross-sectional area could be detected by ultrasound in patients with COPD compared with healthy subjects, and that measurements relate to strength and fat-free mass (FFM).
Methods
Rectus femoris muscle cross-sectional area (RFCSA) was measured by ultrasound and whole-body FFM estimated using electrical bioimpedance. Quadriceps strength was measured by maximum voluntary contraction and twitch tension (TwQ) following magnetic femoral nerve stimulation.
Results
26 healthy volunteers of mean (SD) age 63 (9) years and 30 patients with COPD of mean (SD) age 67 (9) years and percentage predicted forced expiratory volume in 1 s (FEV1) 48.0 (20.8)% with a similar FFM (46.9 (9.3) kg vs 46.1 (7.3) kg, p = 0.193) participated in …
Total citations
Scholar articles
JM Seymour, K Ward, PS Sidhu, Z Puthucheary… - Thorax, 2009