Authors
Jasvinder Kaler, Joerg Steier, Panagis Drakatos, Grainne d’Ancona, Rexford Muza, Elaine Lyons, Jessica Clements, Laura Perez Carbonell, Brian D Kent, Guy D Leschziner
Publication date
2023/10/1
Source
BMJ Open Respiratory Research
Volume
10
Issue
Suppl 1
Publisher
Archives of Disease in childhood
Description
Introduction
Restless legs syndrome (RLS) is a common debilitating neurological disorder. Midbrain iron deficiency has been implicated in the pathophysiology of RLS. There is evidence that supports the use of ferric carboxymaltose (FCM) in ameliorating RLS severity. This study aims to evaluate the effectiveness of FCM in a cohort with refractory RLS.
Methods
Clinically eligible patients with diagnosed RLS from Guy’s Sleep Disorder Centre, who received single-dose FCM 1000mg as per clinic protocol between January 2020 and January 2023 were included. Electronic patient records were retrospectively reviewed. Ferritin levels and percentage transferrin saturation (TSat%) were recorded at baseline and at 12-weeks post-infusion of FCM. The severity of RLS symptoms as per International RLS Study Group rating scale (IRLS) (range 0–40), was recorded at the same intervals.
Results
Twenty patients (age 51.1 …
Scholar articles
J Kaler, J Steier, P Drakatos, G d'Ancona, R Muza… - 2023