Authors
BF Sparks, SD Friedman, DW Shaw, Elizabeth H Aylward, D Echelard, AA Artru, KR Maravilla, JN Giedd, J Munson, G Dawson, SR Dager
Publication date
2002/7/23
Journal
Neurology
Volume
59
Issue
2
Pages
184-192
Publisher
Lippincott Williams & Wilkins
Description
Objective: To explore the specific gross neuroanatomic substrates of this brain developmental disorder, the authors examine brain morphometric features in a large sample of carefully diagnosed 3- to 4-year-old children with autism spectrum disorder (ASD) compared with age-matched control groups of typically developing (TD) children and developmentally delayed (DD) children.
Methods: Volumes of the cerebrum, cerebellum, amygdala, and hippocampus were measured from three-dimensional coronal MR images acquired from 45 children with ASD, 26 TD children, and 14 DD children. The volumes were analyzed with respect to age, sex, volume of the cerebrum, and clinical status.
Results: Children with ASD were found to have significantly increased cerebral volumes compared with TD and DD children. Cerebellar volume for the ASD group was increased in comparison with the TD group, but this …
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BF Sparks, SD Friedman, DW Shaw, EH Aylward… - Neurology, 2002