Authors
Girijesh K Verma, Keshav Raghuvanshi, Ram Kumar, Maya Shankar Singh
Publication date
2012/1/25
Journal
Tetrahedron Letters
Volume
53
Issue
4
Pages
399-402
Publisher
Pergamon
Description
A simple, efficient, and high yielding one-pot protocol for the synthesis of pyrimido[4,5-b]quinolines and indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidines has been developed by three-component domino coupling of 6-amino-1,3-dimethyluracil, aldehydes, and cyclic 1,3-diketones in ecofriendly solvent water promoted by PTSA. The protocol avoids the use of expensive catalysts, toxic solvents, and chromatographic separation. The generality and functional tolerance of this convergent and environmentally benign method is demonstrated.
Scholar articles
GK Verma, K Raghuvanshi, R Kumar, MS Singh - Tetrahedron Letters, 2012