Authors
Gaurav Shukla, Abhijeet Srivastava, Anugula Nagaraju, Keshav Raghuvanshi, Maya Shankar Singh
Publication date
2015/12/14
Journal
Advanced Synthesis & Catalysis
Volume
357
Issue
18
Pages
3969-3976
Publisher
WILEY‐VCH Verlag
Description
The direct α‐Csp2H functionalization and thiomethylation of α‐oxoketene dithioacetals (DTAs) has been accomplished with dimethyl sulfoxide (DMSO) in the presence of iodine and a copper(I) salt for the first time. A prerequisite is the in situ iodination of the α‐Csp2 atom of dithioacetals that could offer other reaction channels. The operationally simple one‐pot protocol includes region‐defined consecutive iodination and sulfenylation of the challenging α‐Csp2H bond of dithioacetals employing cheap and readily available reagents. DMSO here plays a dual role as thiomethyl source and solvent.
Scholar articles
G Shukla, A Srivastava, A Nagaraju, K Raghuvanshi… - Advanced Synthesis & Catalysis, 2015