View article

The first part of this study first aims at validating a method to identify suspected allergens limited by EU regulations in fragrances by comprehensive two-dimensional gas chromatography (GC×GC) coupled with rapid scanning quadrupole MS (GC×GC-qMS). The effectiveness of the quadrupole MS operating at different scanning speed (1000 and 11,111amu/s) was evaluated in identifying (full scan mode acquisition – TIC) and in quantifying (single ion monitoring – SIM) the target analytes in complex mixtures. In full scan acquisition mode the mass range was reduced to 40–240amu to increase the scan acquisition rate while in SIM mode the influence of different dwell-times (40, 10 and 5ms) was tested. The number of scans for each single modulated chromatographic GC×GC peak and the total number of scans for the 2D peak, together with half height peak width (referred to apex) of each allergen in the standard …