Authors
R Corder, NQ Khan, S Lilley, R Fox, J Tyler, A Angbohang, PW Caton, W Mullen, F Filomena, A Ahluwalia, A Crozier, J Malkinson
Publication date
2023/11
Journal
European Heart Journal
Volume
44
Issue
Supplement_2
Pages
ehad655. 3128
Publisher
Oxford University Press
Description
Background
Cardiovascular disease mortality is reduced in individuals with high daily consumption of dietary polyphenols. Optimal daily intakes, choice of polyphenol, and mechanism of action have yet to be fully defined. Pomegranate juice (PJ) reduces blood pressure and improves endothelial function. These effects are attributed to the high levels of polyphenols, primarily ellagitannins.
Purpose
The aims of these investigations were (1) to identify PJ polyphenol(s) that altered endothelial function and could potentially lower blood pressure, and (2) to compare these endothelial actions to oligomeric procyanidins (OPC) purified from apple polyphenol extracts.
Methods
PJ polyphenols were purified by Sephadex LH-20 chromatography and RP-HPLC, and identified by LC-MS/MS and NMR. Fractions were screened for biological activity using cultured bovine …
Scholar articles
R Corder, NQ Khan, S Lilley, R Fox, J Tyler… - European Heart Journal, 2023