Authors
Rolf D Issels, Lars H Lindner, Jaap Verweij, Peter Wust, Peter Reichardt, Baard-Christian Schem, Sultan Abdel-Rahman, Soeren Daugaard, Christoph Salat, Clemens-Martin Wendtner, Zeljko Vujaskovic, Rüdiger Wessalowski, Karl-Walter Jauch, Hans Roland Dürr, Ferdinand Ploner, Andrea Baur-Melnyk, Ulrich Mansmann, Wolfgang Hiddemann, Jean-Yves Blay, Peter Hohenberger
Publication date
2010/6/1
Journal
The lancet oncology
Volume
11
Issue
6
Pages
561-570
Publisher
Elsevier
Description
Background
The optimum treatment for high-risk soft-tissue sarcoma (STS) in adults is unclear. Regional hyperthermia concentrates the action of chemotherapy within the heated tumour region. Phase 2 studies have shown that chemotherapy with regional hyperthermia improves local control compared with chemotherapy alone. We designed a parallel-group randomised controlled trial to assess the safety and efficacy of regional hyperthermia with chemotherapy.
Methods
Patients were recruited to the trial between July 21, 1997, and November 30, 2006, at nine centres in Europe and North America. Patients with localised high-risk STS (≥5 cm, Fédération Nationale des Centres de Lutte Contre le Cancer [FNCLCC] grade 2 or 3, deep to the fascia) were randomly assigned to receive either neo-adjuvant chemotherapy consisting of etoposide, ifosfamide, and doxorubicin (EIA) alone, or combined with regional …
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Scholar articles
RD Issels, LH Lindner, J Verweij, P Wust, P Reichardt… - The lancet oncology, 2010