Authors
Gina Suzanne Ogilvie, Dirk van Niekerk, Mel Krajden, Laurie W Smith, Darrel Cook, Lovedeep Gondara, Kathy Ceballos, David Quinlan, Marette Lee, Ruth Elwood Martin, Laura Gentile, Stuart Peacock, Gavin CE Stuart, Eduardo L Franco, Andrew J Coldman
Publication date
2018/7/3
Journal
Jama
Volume
320
Issue
1
Pages
43-52
Publisher
American Medical Association
Description
Importance
There is limited information about the relative effectiveness of cervical cancer screening with primary human papillomavirus (HPV) testing alone compared with cytology in North American populations.
Objective
To evaluate histologically confirmed cumulative incident cervical intraepithelial neoplasia (CIN) grade 3 or worse (CIN3+) detected up to and including 48 months by primary HPV testing alone (intervention) or liquid-based cytology (control).
Design, Setting, and Participants
Randomized clinical trial conducted in an organized Cervical Cancer Screening Program in Canada. Participants were recruited through 224 collaborating clinicians from January 2008 to May 2012, with follow-up through December 2016. Women aged 25 to 65 years with no history of CIN2+ in the past 5 years, no history of invasive cervical cancer, or no history of hysterectomy; who have not received a Papanicolaou test within …
Scholar articles
GS Ogilvie, D van Niekerk, M Krajden, LW Smith… - Jama, 2018