Authors
Steffen Weber-Carstens, Joanna Schneider, Tobias Wollersheim, Anke Assmann, Jeffrey Bierbrauer, Andreas Marg, Hadi Al Hasani, Alexandra Chadt, Katrin Wenzel, Susanne Koch, Jens Fielitz, Christian Kleber, Katharina Faust, Knut Mai, Claudia D Spies, Friedrich C Luft, Michael Boschmann, Joachim Spranger, Simone Spuler
Publication date
2013/2/15
Journal
American journal of respiratory and critical care medicine
Volume
187
Issue
4
Pages
387-396
Publisher
American Thoracic Society
Description
Rationale: Critical illness myopathy (CIM) has no known cause and no treatment. Immobilization and impaired glucose metabolism are implicated.
Objectives: We assessed signal transduction in skeletal muscle of patients at risk for CIM. We also investigated the effects of evoked muscle contraction.
Methods: In a prospective observational and interventional pilot study, we screened 874 mechanically ventilated patients with a sepsis-related organ-failure assessment score greater than or equal to 8 for 3 consecutive days in the first 5 days of intensive care unit stay. Thirty patients at risk for CIM underwent euglycemic-hyperinsulinemic clamp, muscle microdialysis studies, and muscle biopsies. Control subjects were healthy. In five additional patients at risk for CIM, we performed corresponding analyses after 12-day, daily, unilateral electrical muscle stimulation with the contralateral leg as control.
Measurements and …
Scholar articles
S Weber-Carstens, J Schneider, T Wollersheim… - American journal of respiratory and critical care …, 2013