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In this chapter we present a methodology for introducing and maintaining ontology based knowledge management applications into enterprises with a focus on Knowledge Processes and Knowledge Meta Processes. While the former process circles around the usage of ontologies, the latter process guides their initial set up.We illustrate our methodology by an example from a case study on skills management. The methodology serves as a scaffold for Part B “Ontology Engineering” of the handbook. It shows where more specific concerns of ontology engineering find their place and how they are related in the overall process.