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In this paper, we introduce a distributed dynamic routing algorithm in multi-hop cognitive radio (CR) networks, in which secondary users (SUs) want to minimize their interference to the primary users (PUs) while keeping the delay along the route low. We employ a cognitive pilot channel (CPC) for SUs to be able to access the information about PUs, including PUs' locations and channel conditions. Medial axis with a relaxation factor is used as a reference path for the routing, along which we develop a hierarchical structure for multiple sources to reach their destinations. We introduce a temporal and spatial dynamic non-cooperative game to model the interactions among the SUs as well as their influences on the PUs, and obtain by backward induction a set of mixed (behavioral) Nash equilibrium strategies. We also employ a multi-stage fictitious play learning algorithm for distributed routing, which minimizes the …