Authors
David R Murdoch, G Ralph Corey, Bruno Hoen, José M Miró, Vance G Fowler, Arnold S Bayer, Adolf W Karchmer, Lars Olaison, Paul A Pappas, Philippe Moreillon, Stephen T Chambers, Vivian H Chu, Vicenç Falcó, David J Holland, Philip Jones, John L Klein, Nigel J Raymond, Kerry M Read, Marie Francoise Tripodi, Riccardo Utili, Andrew Wang, Christopher W Woods, Christopher H Cabell, International Collaboration on Endocarditis–Prospective Cohort Study (ICE-PCS) Investigators
Publication date
2009/3/9
Journal
Archives of internal medicine
Volume
169
Issue
5
Pages
463-473
Publisher
American Medical Association
Description
Background
We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide.
Methods
Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005.
Results
The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hallmarks of IE. Recent health care exposure was found in one-quarter of patients.Staphylococcus aureuswas the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac …
Total citations
Scholar articles
DR Murdoch, GR Corey, B Hoen, JM Miró, VG Fowler… - Archives of internal medicine, 2009