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Slow earthquakes including tremor and slow-slip events are recent additions to the conventional earthquake family and have a close link to megathrust earthquakes. Slow earthquakes along the Cascadia subduction zone display a diverse behavior at different spatiotemporal scales and an intriguing increase of events frequency with depth. However, what causes such variability, especially the depth-dependent behavior is not well understood. Here we build on a heterogeneous asperities-in-matrix fault model that incorporates differential pore pressure in a rate-and-state friction framework to investigate the underlying processes of the observed episodic tremor and slow-slip (ETS) variability. We find that the variations of effective normal stress (pore pressure) is one important factor in controlling ETS behavior. Our model reproduces the full complexity of ETS patterns and the depth-frequency scaling that agree …