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Based on previously developed Mode Pursuing Sampling (MPS) approach for continuous variables, a variation of MPS for discrete variable global optimization problems on expensive black-box functions is developed in this paper. The proposed method, namely, the discrete variable MPS (D-MPS) method, differs from its continuous variable version not only on sampling in a discrete space, but moreover, on a novel double-sphere strategy. The double-sphere strategy features two hyperspheres whose radii are dynamically enlarged or shrunk in control of, respectively, the degree of “exploration” and “exploitation” in the search of the optimum. Through testing and application to design problems, the proposed D-MPS method demonstrates excellent efficiency and accuracy as compared to the best results in literature on the test problems. The proposed method is believed a promising global optimization strategy for …