Authors
Daneng Li, Can-Lan Sun, Heeyoung Kim, Enrique Soto-Perez-de-Celis, Vincent Chung, Marianna Koczywas, Marwan Fakih, Joseph Chao, Leana Cabrera Chien, Kemeberly Charles, Simone Fernandes Dos Santos Hughes, Vani Katheria, Monica Trent, Elsa Roberts, Reena Jayani, Jeanine Moreno, Cynthia Kelly, Mina S Sedrak, William Dale
Publication date
2021/11/1
Journal
JAMA oncology
Volume
7
Issue
11
Pages
e214158-e214158
Publisher
American Medical Association
Description
Importance
Although geriatric assessment–driven intervention improves patient-centered outcomes, its influence on chemotherapy-related toxic effects remains unknown.
Objective
To assess whether specific geriatric assessment–driven intervention (GAIN) can reduce chemotherapy-related toxic effects in older adults with cancer.
Design, Setting, and Participants
A randomized clinical trial enrolled 613 participants from a National Cancer Institute–designated cancer center between 2015 and 2019. Patients were 65 years and older with a solid malignant neoplasm, were starting a new chemotherapy regimen, and completed a geriatric assessment. Patients were followed up until chemotherapy completion or 6 months after initiation, whichever occurred first. Data analysis was done by intention-to-treat principle.
Interventions
Patients were randomized (2:1) to either the GAIN (intervention) or standard of care (SOC) arm …
Total citations
Scholar articles
D Li, CL Sun, H Kim, E Soto-Perez-de-Celis, V Chung… - JAMA oncology, 2021