Authors
Alfonso Cristaudo, Rudy Foddis, Agnese Vivaldi, Giovanni Guglielmi, Nicola Dipalma, Rosangela Filiberti, Monica Neri, Marcello Ceppi, Michela Paganuzzi, Gian Paolo Ivaldi, Manlio Mencoboni, Pier Aldo Canessa, Nicolino Ambrosino, Antonio Chella, Luciano Mutti, Riccardo Puntoni
Publication date
2007/9/1
Journal
Clinical Cancer Research
Volume
13
Issue
17
Pages
5076-5081
Publisher
American Association for Cancer Research
Description
Purpose: High levels of serum-soluble mesothelin family proteins (SMRP) have been found to be associated with malignant mesothelioma (MM), but not lung cancer (LC). To verify the clinical role of this marker for both these tumors, we tested serum SMRP in the largest population of thoracic cancers ever assembled.
Experimental Design: SMRP blood concentrations were measured in 107 patients with MM, 215 patients with LC, 130 patients with benign respiratory diseases (BRD), and 262 controls. Statistical comparison between mean serum SMRP levels in all groups was done and receiver operating characteristic curves were constructed to evaluate the performance of this marker.
Results: SMRP levels were significantly higher in patients with MM and LC than in patients with benign respiratory diseases and controls (P < 0.001). The area under the receiver operating …
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