Authors
Francesca Poggio, Marco Bruzzone, Marcello Ceppi, NF Pondé, G La Valle, Lucia Del Mastro, Evandro de Azambuja, Matteo Lambertini
Publication date
2018/7/1
Source
Annals of Oncology
Volume
29
Issue
7
Pages
1497-1508
Publisher
Elsevier
Description
Background
The role of platinum-based neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) patients is highly controversial and it is not endorsed by current guidelines. Our meta-analysis aimed to better elucidate its activity, efficacy and safety.
Material and methods
A systematic search of Medline, Web of Science and conferences proceedings up to 30 October 2017 was carried out to identify randomized controlled trials (RCTs) investigating platinum-based versus platinum-free neoadjuvant chemotherapy in TNBC patients. Using the fixed and random effects models, pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CI) were calculated for pathological complete response (pCR, defined as ypT0/is pN0), event-free survival (EFS), overall survival (OS) and grade 3 and 4 adverse events (AEs: neutropenia, anemia, thrombocytopenia and neuropathy).
Results
Nine RCTs (N …
Scholar articles
F Poggio, M Bruzzone, M Ceppi, NF Pondé, G La Valle… - Annals of Oncology, 2018