Authors
Lucia Del Mastro, Marcello Ceppi, Francesca Poggio, Claudia Bighin, Fedro Peccatori, Isabelle Demeestere, Alessia Levaggi, Sara Giraudi, Matteo Lambertini, Alessia D’Alonzo, Giuseppe Canavese, Paolo Pronzato, Paolo Bruzzi
Publication date
2014/6/1
Source
Cancer treatment reviews
Volume
40
Issue
5
Pages
675-683
Publisher
WB Saunders
Description
Background
The role of temporary ovarian suppression with gonadotropin-releasing hormone analogues (GnRHa) in the prevention of chemotherapy-induced premature ovarian failure (POF) is still controversial. We conducted a systematic review and meta-analysis of randomized trials evaluating the efficacy of GnRHa, given before and during chemotherapy, in the prevention of POF in premenopausal cancer patients.
Methods
Studies were retrieved by searching PubMed, Web of Knowledge database and the proceedings of major conferences. We calculated Odds Ratios (OR) and 95% confidence intervals (CIs) for POF from each trial and obtained pooled estimates through the random effects model as suggested by DerSimonian and Laird.
Results
Nine studies were included in the meta-analysis with 225 events of POF occurring in 765 analyzed patients. The pooled OR estimate indicates a highly significant …
Scholar articles
L Del Mastro, M Ceppi, F Poggio, C Bighin, F Peccatori… - Cancer treatment reviews, 2014