Authors
Stefano Bonassi, Michael Fenech, Cecilia Lando, Yi‐ping Lin, Marcello Ceppi, Wushou Peter Chang, Nina Holland, Micheline Kirsch‐Volders, Errol Zeiger, Sadayuki Ban, Roberto Barale, Maria Paola Bigatti, Claudia Bolognesi, Cao Jia, Marina Di Giorgio, Lynnette R Ferguson, Aleksandra Fucic, Omar Garcia Lima, Patrizia Hrelia, Ayyathan P Krishnaja, Tung‐Kwang Lee, Lucia Migliore, Ludmilla Mikhalevich, Ekaterina Mirkova, Pasquale Mosesso, Wolfgang‐Ulrich Müller, Youichi Odagiri, Maria Rosaria Scarffi, Elena Szabova, Irena Vorobtsova, Anne Vral, Andrea Zijno
Publication date
2001
Journal
Environmental and molecular mutagenesis
Volume
37
Issue
1
Pages
31-45
Publisher
John Wiley & Sons, Inc.
Description
Micronucleus (MN) expression in peripheral blood lymphocytes is well established as a standard method for monitoring chromosome damage in human populations. The first results of an analysis of pooled data from laboratories using the cytokinesis‐block micronucleus (CBMN) assay and participating in the HUMN (HUman MicroNucleus project) international collaborative study are presented. The effects of laboratory protocol, scoring criteria, and host factors on baseline micronucleated binucleate cell (MNC) frequency are evaluated, and a reference range of “normal” values against which future studies may be compared is provided. Primary data from historical records were submitted by 25 laboratories distributed in 16 countries. This resulted in a database of nearly 7000 subjects. Potentially significant differences were present in the methods used by participating laboratories, such as in the type of culture …
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Scholar articles
S Bonassi, M Fenech, C Lando, Y Lin, M Ceppi… - Environmental and molecular mutagenesis, 2001