Authors
Stefano Bonassi, Ariana Znaor, Marcello Ceppi, Cecilia Lando, Wushou Peter Chang, Nina Holland, Micheline Kirsch-Volders, Errol Zeiger, Sadayuki Ban, Roberto Barale, Maria Paola Bigatti, Claudia Bolognesi, Antonina Cebulska-Wasilewska, Eleonora Fabianova, Alexandra Fucic, Lars Hagmar, Gordana Joksic, Antonietta Martelli, Lucia Migliore, Ekaterina Mirkova, Maria Rosaria Scarfi, Andrea Zijno, Hannu Norppa, Michael Fenech
Publication date
2007/3/1
Journal
Carcinogenesis
Volume
28
Issue
3
Pages
625-631
Publisher
Oxford University Press
Description
The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence has been accumulated supporting the causal role of MN induction in cancer development, although prospective cohort studies are needed to validate MN as a cancer risk biomarker. A total of 6718 subjects from of 10 countries, screened in 20 laboratories for MN frequency between 1980 and 2002 in ad hoc studies or routine cytogenetic surveillance, were selected from the database of the HUman MicroNucleus (HUMN) international collaborative project and followed up for cancer incidence or mortality. To standardize for the inter-laboratory variability subjects were classified according to the percentiles of MN distribution within each laboratory as low, medium or high frequency. A …
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Scholar articles
S Bonassi, A Znaor, M Ceppi, C Lando, WP Chang… - Carcinogenesis, 2007