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The present paper reviews research in the area of the broad‐spectrum chemotherapeutic agent cisplatin (cis‐diamminedichloro‐platinum II) and examines the implications for clinical neuropsychology arising from the neurological disruption associated with cisplatin‐based therapy. The paper begins with a brief review of cisplatin treatment in terms other than survival alone, and examines the side‐effects and the potential central nervous system (CNS) dysfunction in terms of neurological symptoms and concomitant implications for neuropsychology. Two main implications for clinical neuropsychology arising from cisplatin therapy are identified. First, cisplatin therapy impacts upon the psychological well‐being of the patient, particularly during and in the months following treatment. It is suggested that during this time, a primary role for neuropsychology is to focus upon the monitoring and the active enhancement of the …