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End-to-End deep learning has shown promising results for speech enhancement tasks, such as noise suppression, dereverberation, and speech separation. However, most state-of-the-art methods for echo cancellation are either classical DSP-based or hybrid DSP-ML algorithms. Components such as the delay estimator and adaptive linear filter are based on traditional signal processing concepts, and deep learning algorithms typically only serve to replace the non-linear residual echo suppressor. This paper introduces an end-to-end echo cancellation network with a streaming cross-attention alignment (SCA). Our proposed method can handle unaligned inputs without requiring external alignment and generate high-quality speech without echoes. At the same time, the end-to-end algorithm simplifies the current echo cancellation pipeline for time-variant echo path cases. We test our proposed method on the …