Authors
Najib M El-Sayed, Peter J Myler, Gaëlle Blandin, Matthew Berriman, Jonathan Crabtree, Gautam Aggarwal, Elisabet Caler, Hubert Renauld, Elizabeth A Worthey, Christiane Hertz-Fowler, Elodie Ghedin, Christopher Peacock, Daniella C Bartholomeu, Brian J Haas, Anh-Nhi Tran, Jennifer R Wortman, U Cecilia M Alsmark, Samuel Angiuoli, Atashi Anupama, Jonathan Badger, Frederic Bringaud, Eithon Cadag, Jane M Carlton, Gustavo C Cerqueira, Todd Creasy, Arthur L Delcher, Appolinaire Djikeng, T Martin Embley, Christopher Hauser, Alasdair C Ivens, Sarah K Kummerfeld, Jose B Pereira-Leal, Daniel Nilsson, Jeremy Peterson, Steven L Salzberg, Joshua Shallom, Joana C Silva, Jaideep Sundaram, Scott Westenberger, Owen White, Sara E Melville, John E Donelson, Björn Andersson, Kenneth D Stuart, Neil Hall
Publication date
2005/7/15
Journal
Science
Volume
309
Issue
5733
Pages
404-409
Publisher
American Association for the Advancement of Science
Description
A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that—along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions—have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.
Total citations
Scholar articles
NM El-Sayed, PJ Myler, G Blandin, M Berriman… - Science, 2005