Authors
RICARDO Gazzinelli, YuHui Xu, SARA Hieny, ALLEN Cheever, ALAN Sher
Publication date
1992/7/1
Journal
Journal of immunology (Baltimore, Md.: 1950)
Volume
149
Issue
1
Pages
175-180
Description
C57BL/6 mice chronically infected with an avirulent strain (ME-49) of Toxoplasma gondii were used to study the mechanisms by which T lymphocytes and IFN-gamma prevent reactivation of latent infection. Infected animals were treated with mAb, either anti-CD8, anti-CD4, anti-CD4 plus anti-CD8, anti-IFN-gamma, or anti-CD4 plus anti-IFN-gamma and the mice followed for survival, histopathology, cyst numbers, and spleen cell cytokine responses. In agreement with previously published findings, treatment with anti-IFN-gamma antibodies fully reactivated the asymptomatic infection, inducing massive necrotic areas in the brain with the appearance of free tachyzoites and death of all animals within 2 wk. Mice treated with the combination of anti-CD4 plus anti-CD8 antibodies showed augmented pathology and mortality nearly identical to the anti-IFN-gamma- treated animals. In contrast, treatment with anti-CD4 or …
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Scholar articles
R Gazzinelli, YH Xu, S Hieny, A Cheever, A Sher - Journal of immunology (Baltimore, Md.: 1950), 1992