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Alkylation of carboxylic acids in a microfluidic device: kinetics parameters determination, Hammett reaction constant measurement and optimization of preparative experiment.

Authors

Azarmidokht Gholamipour-Shirazi, Maël Penhoat, Christian Rolando

Publication date

2009/11/1

Journal

13rd International Electronic Conference on Synthetic Organic Chemistry (ECSOC-13)

Pages

Description

A new proton sponge 1, 8-bis (tetramethylguanidino) naphthalene (TMGN) was utilized for the alkylation of benzoic acid by iodomethane in a continuous flow microsystem. Using this set-up, kinetics of the reaction was determined in different mixing strategies and the Hammett reaction constant was measured. Good performance and efficiency of this procedure were confirmed through several preparative studies.

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Alkylation of carboxylic acids in a microfluidic device: kinetics parameters determination, Hammett reaction constant measurement and optimization of preparative experiment.

A Gholamipour-Shirazi, M Penhoat, C Rolando - 13rd International Electronic Conference on Synthetic …, 2009

Alkylation of carboxylic acids in a microfluidic device: kinetics parameters determination, Hammett reaction constant measurement and optimization of preparative experiment*

C Rolando, M Penhoat, A Gholamipour-Shirazi - 2009